Jornada 1
| 07 Sep 21 |  Platense |
4 - 0 |  Parque |
... |
| 07 Sep 21 |  Alto Perú |
1 - 1 |  Huracán |
... |
| 07 Sep 21 |  Huracán |
3 - 1 |  Fondo |
... |
| 07 Sep 21 |  Paysandú |
0 - 0 |  Halcones |
... |
| 07 Sep 21 |  Deportivo |
2 - 2 |  Salus |
... |
| 07 Sep 21 |  Artigas |
0 - 3 |  Oriental |
... |
| 08 Sep 21 |  Colón FC |
1 - 2 |  Potencia |
... |
| 08 Sep 21 |  Salto FC |
0 - 0 |  Basáñez |
... |
| 08 Sep 21 |  Miramar |
2 - 3 |  Bella Vista |
... |
| 09 Sep 21 |  Canadian |
0 - 2 |  La Luz FC |
... |
Jornada 2
| 11 Sep 21 | Huracán |
0 - 1 | Huracán |
... |
| 11 Sep 21 | Basáñez |
2 - 0 | Miramar |
... |
| 11 Sep 21 | Potencia |
1 - 0 | Deportivo |
... |
| 12 Sep 21 | Parque |
0 - 1 | Artigas |
... |
| 12 Sep 21 | La Luz FC |
3 - 1 | Platense |
... |
| 12 Sep 21 | Bella Vista |
2 - 1 | Fondo |
... |
| 12 Sep 21 | Paysandú |
5 - 0 | Alto Perú |
... |
| 12 Sep 21 | Halcones |
0 - 3 | Salto FC |
... |
| 12 Sep 21 |  Tacuarembó |
1 - 1 | Colón FC |
... |
| 12 Sep 21 | Salus |
2 - 0 | Canadian |
... |
Jornada 3
| 15 Sep 21 | Fondo |
3 - 0 | Huracán |
... |
| 15 Sep 21 | Bella Vista |
1 - 0 | Basáñez |
... |
| 15 Sep 21 | Huracán |
0 - 2 | Paysandú |
... |
| 15 Sep 21 | Miramar |
2 - 0 | Halcones |
... |
| 15 Sep 21 | Alto Perú |
0 - 4 | Salto FC |
... |
| 15 Sep 21 | Oriental |
3 - 1 | Parque |
... |
| 15 Sep 21 | Deportivo |
0 - 3 | Tacuarembó |
... |
| 15 Sep 21 | La Luz FC |
1 - 0 | Artigas |
... |
| 15 Sep 21 | Canadian |
4 - 1 | Potencia |
... |
| 15 Sep 21 | Salus |
2 - 1 | Platense |
... |
Jornada 4
| 18 Sep 21 | Basáñez |
0 - 0 | Fondo |
... |
| 19 Sep 21 | Paysandú |
1 - 1 | Huracán |
... |
| 19 Sep 21 | Halcones |
0 - 1 | Bella Vista |
... |
| 19 Sep 21 | Salto FC |
3 - 2 | Huracán |
... |
| 18 Sep 21 | Miramar |
7 - 0 | Alto Perú |
1 |
| 18 Sep 21 | Colón FC |
2 - 1 | Deportivo |
... |
| 19 Sep 21 | La Luz FC |
0 - 0 | Oriental |
... |
| 19 Sep 21 | Tacuarembó |
3 - 1 | Canadian |
... |
| 18 Sep 21 | Salus |
0 - 0 | Artigas |
... |
| 18 Sep 21 | Potencia |
0 - 1 | Platense |
... |
Jornada 5
| 26 Sep 21 | Fondo |
1 - 1 | Paysandú |
... |
| 26 Sep 21 | Basáñez |
4 - 0 | Halcones |
... |
| 25 Sep 21 | Huracán |
1 - 1 | Salto FC |
... |
| 25 Sep 21 | Bella Vista |
1 - 0 | Alto Perú |
... |
| 26 Sep 21 | Huracán |
1 - 4 | Miramar |
... |
| 23 Sep 21 | Parque |
0 - 2 | La Luz FC |
... |
| 22 Sep 21 | Canadian |
1 - 1 | Colón FC |
... |
| 22 Sep 21 | Oriental |
1 - 1 | Salus |
... |
| 22 Sep 21 | Platense |
0 - 3 | Tacuarembó |
... |
| 21 Sep 21 | Artigas |
4 - 0 | Potencia |
... |
Jornada 6
| 29 Sep 21 | Halcones |
1 - 1 | Fondo |
... |
| 29 Sep 21 | Salto FC |
0 - 0 | Paysandú |
1 |
| 29 Sep 21 | Alto Perú |
0 - 3 | Basáñez |
... |
| 29 Sep 21 | Miramar |
2 - 2 | Huracán |
... |
| 29 Sep 21 | Huracán |
0 - 0 | Bella Vista |
... |
| 26 Sep 21 | Canadian |
1 - 2 | Deportivo |
... |
| 26 Sep 21 | Parque |
0 - 1 | Salus |
... |
| 26 Sep 21 | Platense |
2 - 5 | Colón FC |
... |
| 26 Sep 21 | Oriental |
0 - 0 | Potencia |
... |
| 25 Sep 21 | Artigas |
1 - 1 | Tacuarembó |
... |
Jornada 7
| 03 Oct 21 | Fondo |
0 - 2 | Salto FC |
... |
| 02 Oct 21 | Halcones |
2 - 2 | Alto Perú |
... |
| 03 Oct 21 | Paysandú |
1 - 1 | Miramar |
... |
| 03 Oct 21 | Basáñez |
2 - 1 | Huracán |
... |
| 03 Oct 21 | Huracán |
1 - 0 | Bella Vista |
... |
| 29 Sep 21 | Salus |
1 - 2 | La Luz FC |
... |
| 29 Sep 21 | Deportivo |
2 - 3 | Platense |
... |
| 29 Sep 21 | Potencia |
2 - 4 | Parque |
... |
| 29 Sep 21 | Colón FC |
1 - 1 | Artigas |
... |
| 29 Sep 21 | Tacuarembó |
2 - 1 | Oriental |
... |
Jornada 8
| 10 Oct 21 | Alto Perú |
1 - 2 | Fondo |
... |
| 09 Oct 21 | Miramar |
1 - 0 | Salto FC |
... |
| 10 Oct 21 | Huracán |
1 - 2 | Halcones |
... |
| 09 Oct 21 | Bella Vista |
2 - 1 | Paysandú |
... |
| 10 Oct 21 | Huracán |
1 - 1 | Basáñez |
... |
| 02 Oct 21 | Platense |
0 - 1 | Canadian |
... |
| 02 Oct 21 | La Luz FC |
4 - 0 | Potencia |
... |
| 02 Oct 21 | Artigas |
0 - 0 | Deportivo |
... |
| 02 Oct 21 | Parque |
1 - 3 | Tacuarembó |
... |
| 03 Oct 21 | Oriental |
0 - 3 | Colón FC |
... |
Jornada 9
| 13 Oct 21 | Fondo |
0 - 2 | Miramar |
... |
| 14 Oct 21 | Alto Perú |
1 - 1 | Huracán |
1 |
| 14 Oct 21 | Salto FC |
1 - 1 | Bella Vista |
... |
| 13 Oct 21 | Halcones |
0 - 3 | Huracán |
... |
| 13 Oct 21 | Paysandú |
1 - 2 | Basáñez |
... |
| 06 Oct 21 | Potencia |
1 - 2 | Salus |
... |
| 06 Oct 21 | Canadian |
2 - 1 | Artigas |
1 |
| 06 Oct 21 | Tacuarembó |
1 - 1 | La Luz FC |
... |
| 06 Oct 21 | Deportivo |
0 - 1 | Oriental |
... |
| 06 Oct 21 | Colón FC |
2 - 2 | Parque |
... |
Jornada 10