Jornada 1
| 18 Sep 21 |  Lyuban |
3 - 0 |  Krupki |
... |
| 18 Sep 21 |  Smolevichy |
0 - 3 |  Kronon |
... |
| 18 Sep 21 |  Falko |
5 - 2 |  Energosbyt- |
... |
| 18 Sep 21 |  Viktoriya |
1 - 0 |  Kolos |
... |
| 18 Sep 21 |  Berezino |
1 - 3 |  Spartak |
... |
| 18 Sep 21 |  Kletsk |
4 - 11 |  Autotrans |
... |
| 18 Sep 21 |  Molodechno |
0 - 0 |  Partizan |
... |
| 18 Sep 21 |  Starye |
3 - 0 |  Viliya |
... |
| 19 Sep 21 |  BGU Minsk |
2 - 1 |  FK Uzda |
... |
| 19 Sep 21 |  Edinstvo |
0 - 1 |  Stroitel |
... |
Jornada 2
| 02 Oct 21 |  Osipovichy |
1 - 1 |  Gazovik |
... |
| 10 Oct 21 | Gazovik |
1 - 2 | Osipovichy |
... |
| 02 Oct 21 |  Dinamo |
2 - 0 | FK Uzda |
... |
| 09 Oct 21 | FK Uzda |
1 - 5 | Dinamo |
... |
| 02 Oct 21 | Viktoriya |
1 - 6 |  Stenles |
... |
| 10 Oct 21 | Stenles |
0 - 1 | Viktoriya |
... |
| 02 Oct 21 |  BC Maxline |
3 - 0 |  Bumprom |
... |
| 09 Oct 21 | Bumprom |
1 - 4 | BC Maxline |
... |
| 02 Oct 21 |  Niva |
0 - 3 |  Ostrovets |
... |
| 09 Oct 21 | Ostrovets |
5 - 2 | Niva |
... |
| 03 Oct 21 | BGU Minsk |
0 - 0 | Molodechno |
... |
| 10 Oct 21 | Molodechno |
0 - 0 | BGU Minsk |
... |
| 03 Oct 21 | Partizan |
4 - 0 |  Senno |
... |
| 10 Oct 21 | Senno |
0 - 8 | Partizan |
... |
| 03 Oct 21 |  Dnepr |
9 - 1 |  Slonim City |
... |
| 10 Oct 21 | Slonim City |
0 - 0 | Dnepr |
... |
Jornada 3
| 16 Oct 21 | Ostrovets |
2 - 1 | Dinamo |
... |
| 24 Oct 21 | Dinamo |
3 - 2 | Ostrovets |
... |
| 16 Oct 21 | Osipovichy |
2 - 1 | Stenles |
... |
| 23 Oct 21 | Stenles |
3 - 3 | Osipovichy |
... |
| 17 Oct 21 | Partizan |
1 - 0 | Dnepr |
... |
| 23 Oct 21 | Dnepr |
0 - 2 | Partizan |
... |
| 17 Oct 21 | BGU Minsk |
0 - 0 | BC Maxline |
... |
| 24 Oct 21 | BC Maxline |
5 - 2 | BGU Minsk |
... |
Jornada 4
| 30 Oct 21 | BC Maxline |
1 - 2 | Osipovichy |
... |
| 06 Nov 21 | Osipovichy |
2 - 4 | BC Maxline |
... |
| 30 Oct 21 | Partizan |
0 - 0 | Ostrovets |
... |
| 06 Nov 21 | Ostrovets |
3 - 0 | Partizan |
... |
Molodechno
Osipovichy
Smolevichy
Kletsk
FK Stenles Pinsk
Kronon
FK Uzda
Bumprom
Energosbyt-BSATU
Ostrovets
Niva Dolbizno
Partizan Salihorsk
SMI Autotrans
BGU Minsk
Gazovik Vitebsk
Dinamo Malorita
Viktoriya Maryina Horka
Kolos Cherven
Senno
Berezino
Edinstvo Dzerzhinsk
Falko
Krupki
Lyuban
Spartak Slutsk
Viliya
Dnepr Mogilev II
Slonim City
Starye Dorogi
BC Maxline
Stroitel Kapyl